Ameisen als Objekte gerontologischer Forschung

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Ameisen als Objekte gerontologischer Forschung

Beitragvon Merkur » Montag 18. Februar 2019, 09:37

An der Lomonosov Moscow State University forscht eine Gruppe von Wissenschaftlern über das Altern. Ameisen mit ihren oft enormen Unterschieden in der Lebenserwartung von Königinnen (viele Jahre) und Arbeiterinnen (oft nur einige Monate bis 2-3 Jahre), Individuen mit gleichem Genom, sollen dazu dienen, das normale Altern sowie Medikamente gegen das Altern (anti-aging drugs) zu untersuchen.
G. A. Shilovsky, T. S. Putyatina, Vasily Ashapkin, A. A. Rozina, V. A. Lyubetsky, E. P. Minina, I. B. Bychkovskaia, A. V. Markov, Vladimir Petrovich Skulachev 2018: Ants as Object of Gerontological Research. - Biochemistry (Moscow) 83(12-13):1489-1503
DOI: 10.1134/S0006297918120076

Social insects with identical genotype that form castes with radically different lifespans are a promising model system for studying the mechanisms underlying longevity. The main direction of progressive evolution of social insects, in particular, ants, is the development of the social way of life inextricably linked with the increase in the colony size. Only in a large colony, it is possible to have a developed polyethism, create large food reserves, and actively regulate the nest micro–climate. The lifespan of ants hugely varies among genetically similar queens, workers (unproductive females), and males. The main advantage of studies on insects is the determinism of ontogenetic processes, with a single genome leading to completely different lifespans in different castes. This high degree of determinacy is precisely the reason why some researchers (incorrectly) call a colony of ants the “superorganism”, emphasizing the fact that during the development, depending on the community needs, ants can switch their ontogenetic programs, which influences their social roles, ability to learn (i.e., the brain [mushroom–like body] plasticity), and, respectively, the spectrum of tasks performed by a given individual. It has been shown that in many types of food behavior, older ants surpass young ones in both performing the tasks and transferring the experience. The balance between the need to reduce the “cost” of non–breeding individuals (short lifespan and small size of workers) and the benefit from experienced long–lived workers possessing useful skills (large size and “non–aging”) apparently determines the differences in the lifespan and aging rate of workers in different species of ants. A large spectrum of rigidly determined ontogenetic trajectories in different castes with identical genomes and the possibility of comparison between “evolutionarily advanced” and “primitive” subfamilies (e.g., Formicinae and Ponerinae) make ants an attractive object in the studies of both normal aging and effects of anti–aging drugs.

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